HPV associated with vaginal intraepithelial neoplasia in women exposed to DES in utero

The role of human papillomavirus and herpes simplex virus in the etiology of intraepithelial neoplasia is discussed in this 1987 study.

Study Abstract

Human papillomavirus associated with vaginal intraepithelial neoplasia in women exposed to diethylstilbestrol in utero, Obstetrics and gynecology, NCBI PubMed PMID: 3037458,
1987 Jul.

Five out of 959 young women, exposed to diethylstilbestrol (DES) in utero, developed vaginal intraepithelial neoplasia while they were under follow-up in the Diethylstilbestrol-Adenosis Project at Baylor College of Medicine, Houston, Texas.

We suggest that the development of the vaginal intraepithelial neoplasia at a younger age than usual may be caused by a higher susceptibility of the DES-exposed patient to factors associated with the development of intraepithelial neoplasia. A common finding in all five women was the detection of the deoxyribonucleic acid (DNA) of human papillomavirus types 6 or 16 in their lesions, using high-stringency in situ hybridization.

The role of human papillomavirus and herpes simplex virus in the etiology of intraepithelial neoplasia is discussed.

Close follow-up is recommended for DES-exposed patients, especially those who have risk factors known to be associated with genital neoplasia.

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