1980 Study Abstract
In this survey of 210 women with a history and/or gross changes of the cervix and vagina characteristic of diethylstilbestrol (DES) exposure, changes related to vaginal adenosis were correlated with age. The mean age of women with columnar epithelium alone was 18.5 +/- 3.2 years, columnar epithelium with squamous metaplasia was 20.2 +/- 3.4 years, and squamous metaplasia alone was 23.0 +/- 2.7 years. These findings suggest that involution of vaginal adenosis occurs with increasing age. Involution of glands in the superficial stroma in most cases occurred concurrently with that of surface columnar epithelium. However, those deeply seated and complex glands in the stroma might lag in the metaplastic process and might persist. The pitfalls of misinterpretation of squamous cell changes in histologic samples were discussed. The lack of correlation between the colposcopic findings of mosaicism and/or punctuation and squamous cell neoplasia was confirmed in this study.
Sources and more information
- A clinicopathologic study of vagina and cervix in DES-exposed progeny, Diagn Gynecol Obstet. 1980 Winter;2(4):245-56, NCBI PMID: 7215109.
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.
2 thoughts on “A clinicopathologic study of vagina and cervix in DES-exposed progeny”
Reblogged this on Barrow Blogs: and commented:
This must not be forgotten. I wrote a fiction built on the facts of DES: http://www.amazon.co.uk/Silent-Trauma-Judith-Barrow-ebook/dp/B00AFZ8CLO