2007 Study Abstract
Dietary substances and xenobiotic compounds with hormone-like activity can disrupt the programming of endocrine signaling pathways that are established during perinatal differentiation. The consequences of this disruption may not be apparent until later in life but increasing evidence implicates developmental exposure to environmental hormone-mimics with a growing list of adverse health effects including reproductive problems and increased cancer risks. Obesity has recently been proposed to be yet another adverse health consequence of exposure to endocrine disrupting substances during development. There is a renewed focus on identifying contributions of environmental factors to the development of obesity since it is reaching worldwide epidemic proportions, and this disease has the potential to overwhelm healthcare systems with associated illnesses such as diabetes and cardiovascular disease. Here, we review the literature that proposes an association of perinatal exposure to endocrine disrupting chemicals, in particular those with estrogenic activity, with the development of obesity later in life. We further describe an animal model of developmental exposure to diethylstilbestrol (DES) to study mechanisms involved in programming for obesity. Our experimental data support the idea that adipocytes and the mechanisms involved in weight homeostasis are novel targets of abnormal programming of environmental estrogens, some of which are found in our foods as naturally occurring substances or inadvertently as contaminants.
- Perinatal exposure to environmental estrogens and the development of obesity,Newbold RR1, Padilla-Banks E, Snyder RJ, Jefferson WN, Mol Nutr Food Res. 2007 Jul;51(7):912-7. NCBI PMID: 17604389.
- Full study: DOI 10.1002/mnfr.200600259, Mol. Nutr. Food Res. 2007, 51, 912 – 917.
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.
4 thoughts on “Perinatal exposure to environmental estrogens and the development of obesity”
Reblogged this on ' Ace Chat News ' and commented:
Added your great post here as well keep well Ian http://flip.it/RwqUc
many thanks Ian
Reblogged this on Milieunet.
many thanks Erik