Stilbosol plus protein… puts more meat on market cattle

DES 1956 advert, FFA National Future Farmer, IUPUI archives

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Stilbosol patenting turned the cattle feed industry upside down in the mid fifties with its phenomenal use by the farmers.
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Exposure to widespread metformin diabetes drug in wastewater feminizes male fish, impacts fertility

Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish

Content from this post is written by Brian Bienkowski and published by Environmental Health News

wastewater discharge image
Male minnows exposed to a widely used diabetes drug ubiquitous in wastewater effluent had feminized reproductive parts and were smaller and less fertile, according to a new study.

It is the first study to examine the drug metformin’s impact on fish endocrine systems and suggests that non-hormone pharmaceuticals pervasive in wastewater may cause reproductive and development problems in exposed fish.

Metformin is largely used to combat insulin resistance associated with type-2 diabetes, which accounts for about 90 percent of all diagnosed U.S. adult diabetes cases.

Researchers from the University of Wisconsin-Milwaukee exposed young fathead minnows to water containing levels of metformin commonly found in wastewater effluent. Eighty-four percent of 31 metformin-exposed male fish exhibited feminized reproductive organs.

Normally in females you see eggs developed in ova, in males, you see a different structure – producing tiny sperm instead of an egg structure,” said Rebecca Klaper, an associate professor at the University of Wisconsin-Milwaukee and senior author of the study. “We saw development of larger egg structures within the [male’s] testis.”

A couple of non-exposed males had very minor feminization, but signs of egg development were nothing compared to what happened in the exposed fish, Klaper said. In addition to the feminization, exposed male minnows weighed less and had significantly less babies when they reproduced, suggesting that the feminization may impact their ability to reproduce properly.

Pharmaceutical chemicals are ubiquitous in wastewater effluent. Researchers estimate that, by mass, metformin is among the most common pharmaceutical in wastewater.

More than nine percent of the U.S. population has diabetes, according to the Centers for Disease Control and Prevention. The agency estimates that from 1980 to 2011, cases of diagnosed diabetes almost tripled.

Increased illnesses means more drugs. Pharmaceutical drugs get into our wastewater when people flush their medication or, more commonly, when they excrete them. Metformin, unlike many pharmaceutical drugs, is not metabolized by the human body, and gets excreted unchanged.

Metformin’s “really been hitting people’s radar more of late,” said Dana Kolpin, a U.S. Geological Survey research hydrologist based in Iowa and project chief of the agency’s emerging contaminants project. Kolpin said as water testing methods have gotten more sophisticated, metformin seems to be one of the most frequently detected. “It’s persistent and mobile,” he said.

Scientists have expressed concern that birth control and other hormone mimicking drugs in water could impact fish populations and cause feminization. Last year U.S. Geological Survey researchers reported intersex fish in Pennsylvania’s Susquehanna, Delaware and Ohio river basins, suggesting that estrogenic chemicals were to blame.

However, metformin is not an estrogenic or hormone-mimicking drug. Rather it is designed to improve insulin sensitivity. It appears a “nontraditional endocrine disrupting chemical,” Klaper and her University of Wisconsin-Milwaukee colleague, Nicholas Niemuth, wrote in the study published in the journal Chemosphere.

While researchers are not totally clear how the drug disrupts fish hormones, metformin has been shown to alter the activity of certain enzymes that are involved in hormone pathways.

We know from some vertebrate studies that insulin and metabolism in an organism is tied into reproduction,” Klaper said. “But how metformin would cause a difference in actual egg production is something we don’t know but is very interesting. Now we’re trying to figure out why.”

Klaper previously found that metformin caused some signs of endocrine disruption when she exposed adult fish to the drug for 28 days. However, no intersex tissue was found, suggesting that exposure during development might be the major concern.

It’s not clear if all fish would react to metformin exposure as the fathead minnows did, Kolpin said. Klaper said the development of male and female fish is not entirely the same across species. She said they would continue testing fathead minnows and also look at zebrafish to see if they exhibit similar impacts.

Kolpin said some waterways also have been shown to have a metformin transformation compound, called guanylurea, which is formed when metformin comes in contact with bacteria such as in sewage.

It’ll be worth finding out if its transformation product also has these bioactive properties,” Kolpin said.

The U.S. Environmental Protection Agency’s latest drinking water contaminant candidate list — water pollutants not subject to regulations yet but that might render water unsafe — includes several pharmaceuticals that act on hormones. Metformin is not on the list, published in February.

Klaper and Niemuth wrote that metformin would probably not show up as an endocrine disruptor under the current testing used by the U.S. EPA Agency, which relies on the binding of chemicals to hormone receptors. Structurally, metformin doesn’t resemble hormones. The results, they argue, suggest the EPA should broaden its testing.

Given its environmental persistence and presence worldwide, this compound merits further research on its potential environmental impacts as well as its impacts on vertebrate development more generally and should be added to the list of potential EDCs [endocrine disrupting chemicals],” Klaper and Niemuth wrote.

2010: Sophie Bonnet enquête sur les nouveaux jackpots des laboratoires pharmaceutiques

Canal+ éclaire les relations étroites entre les compagnies pharmaceutiques, les médecins et les politiques

Du Viagra pour les femmes ou un traitement pour énervés du volant, les labos ne savent plus quoi inventer pour nous faire avaler la pilule. Sophie Bonnet enquête sur leurs techniques marketing, et ça fait mal.

Plus d’information

La pilule contraceptive

On nous cache la vérité depuis 50 ans

Dangers, Alternatives, de Henri Joyeux

Cancers, AVC, thrombo-embolies, dépressions, perte de libido, autisme chez les enfants… de nombreux effets secondaires graves et plusieurs maladies sont impliquées.

Des millions de Françaises prennent la pilule, une contraception hormonale ou un traitement de la ménopause. Mais la plupart ignorent toujours comment fonctionnent ces médicaments et quels effets ils peuvent avoir sur leur corps. Des centaines d’études ont pourtant été publiées dans des revues spécialisées sur les dangers du contraceptif chimique. Cette vérité scientifique est sciemment cachée depuis 50 ans ! Le scandale des pilules de 3e et 4e générations n’est que le premier épisode de ce qui pourrait être la plus grande déroute médicale du XXIe siècle. Saviez-vous que les hormones de synthèse sont au cancer du sein ce que l’amiante est au cancer de la plèvre ? En 1975, on découvrait 7000 cas de nouveaux cancers du sein par an en France. En 2013, nous approchons des 60 000 cas, et chez des femmes de plus en plus jeunes… Cancers, AVC, thrombo-embolies, dépressions, perte de libido, autisme chez les enfants… de nombreux effets secondaires graves et plusieurs maladies sont impliquées. Avec ce livre, les femmes vont enfin comprendre comment fonctionnent la contraception hormonale et le THS. Tout le monde va savoir pourquoi les autorités médicales et la plupart des médecins se taisent et continuent à prescrire des médicaments dangereux. Les femmes pourront choisir en connaissance de cause les nouvelles alternatives contraceptives, sans danger, à leur disposition. La contraception du futur est en marche avec les biotechnologies écologiques !

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What is Androgen Insensitivity Syndrome (AIS) and what it means to be intersex?

What It’s Really Like to Be Intersex.

image of dalea
Musician Dalea talks about how having an atypical body taught her to love herself.

Intersex people are born with a mix of anatomical sex traits (chromosomes, reproductive organs, or genitals). Sometimes they are apparent at birth, sometimes they’re discovered later in life. I have Androgen Insensitivity Syndrome (AIS).

AIS manifests in different ways, yet the key factor is that during gestation, the unborn child develops a resistance to androgens (male hormones), which help build both males and females in the womb. AIS women are born with XY chromosomes, a female appearance, and internal gonads (they can be called testes). AIS variations go from being completely undetectable on the outside at birth, to visible variations on the genitals when the androgen insensitivity is partial. This means that on the outside, a body can look completely like a regular female on one side of the spectrum, to having noticeable traits of both on the other.

My mother was a nurse and when I was born, there were indications of my variation. So my family knew almost right away that something was up. At first it was attributed to a fertility medication that my mom took, called diethylstilbestrol (DES), which caused a lot of issues in babies and mothers until it was taken off the market in the late ’70s. ”

Dalea spoke with Cosmopolitan reporter Kira Peikoff about growing up different, struggling with her body image, and eventually learning how to embrace herself exactly as she is.

Read What It’s Really Like to Be Intersex, Cosmopolitan, APR 16, 2015.

Read DES studies on gender identity.

Is Bought documentary exposing the ugly truth behind Vaccines, GMO’s and Big Pharma?

Vaccines. GMOs. Big Pharma.
Three big, BIG, okay… HUGE topics in one film

The truth behind vaccines, big pharma and your food

More information

DES Action USA Board Meeting, April 2010

The last one around Pat’s dining room table

With Michael Freilick, Litsa Varonis, Pat Cody, Fran Howell, Jill Vanselous Murphy, Kari Christianson.

Taking the photo: Patti Negri.
Image sources: DES Action USA Facebook images.

More DES DiEthylStilbestrol Resources

Thibault Liger-Belair poursuivi pour refus de traiter son vignoble avec un insecticide

Encore un vigneron bio poursuivi en justice pour avoir refusé de polluer

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Thibault Liger-Belair fait partie d’un collectif de vignerons contre la flavescence dorée, créé en décembre 2013 en Bourgogne. Image via La Clef des Terroirs.

Après “l’affaire Emmanuel Giboulot“, un deuxième vigneron est poursuivi en justice pour avoir refusé de traiter son vignoble avec un insecticide!  Thibault Liger-Belair, vigneron bio de Bourgogne, est convoqué au tribunal correctionnel de Villefranche-sur-Saône (Rhône) le 19 mai prochain. Délit en question: “Refus d’effectuer les mesures de protection des végétaux contre les organismes nuisibles en l’espèce : lutte insecticide contre le vecteur de la flavescence dorée“.

Sources et plus d’information

  • Thibault Liger Belair, viticulteur bio : procès reporté au mois de novembre, resistanceinventerre, 20 mai 2015.
  • Un deuxième vigneron bio poursuivi en justice pour avoir refusé de polluer, bastamag, 27 AVRIL 2015.
  • Un nouveau vigneron bourguignon poursuivi pour refus de traiter contre la “flavescence dorée”jeanyvesnau, 2014/28/04.
  • Thibault Liger-Belair bourguignon bio et droit dans ses bottes, thibaultligerbelair, 2012/11.

Les médicaments sont-ils parfois dangereux pour notre santé?

Emission “Le Monde en Face” du 10.02.2015

L’émission “Le Monde en Face” du 10.02.2015 avec M. Carrère d’Encausse, C. Rambaud, I. Frachon, B. Toussaint et P. Errard. Publié le 11 février 2015 par la Journée de l’Épilepsie.

Plus d’information
  • Après la diffusion du documentaire “Médicaments sous influence”, Marina Carrère d’Encausse ouvre le débat avec ses invités, Claude Rambaud, vice-présidente du CISS, un collectif regroupant 40 associations de patients, Bruno Toussaint, rédacteur en chef de la revue mensuelle “Prescrire”, Patrick Errard, président du LEEM, les entreprises du médicament et directeur général d’un laboratoire pharmaceutique, et le docteur Irène Frachon, pneumologue au CHU de Brest, qui a notamment joué un rôle important dans l’affaire du “Mediator”..
  • Regardez cette liste de vidéos sur l’industrie pharmaceutique sur notre chaîne YouTube.

Ordonnance Distilbène, 1970

Regardez le Diaporama et notre album de photos “DES adverts”

Le DES, finalement inefficace pour prévenir les fausses couches, a été retiré des ventes en 1971 aux USA. En France, le Distilbène a continué d’être prescrit jusqu’ en 1977, soit six ans après les Etats-Unis d’Amérique!
Alors, quelle est la responsabilité des médecins?

image d' Ordonnance Distilbène 1970
Regardez le Diaporama, et l’album de photos “DES adverts” sur Flickr.

Le Distilbène DES, en savoir plus:

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