Exposure to hormone-disrupting chemicals is likely leading to an increased risk of serious health problems costing hundreds of billions (U.S.) per year in Europe alone…
2015 Study Abstract
Rapidly increasing evidence has documented that endocrine-disrupting chemicals (EDCs) contribute substantially to disease and disability.
The objective was to quantify a range of health and economic costs that can be reasonably attributed to EDC exposures in the European Union (EU).
A Steering Committee of scientists adapted the Intergovernmental Panel on Climate Change weight-of-evidence characterization for probability of causation based upon levels of available epidemiological and toxicological evidence for one or more chemicals contributing to disease by an endocrine disruptor mechanism. To evaluate the epidemiological evidence, the Steering Committee adapted the World Health Organization Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group criteria, whereas the Steering Committee adapted definitions recently promulgated by the Danish Environmental Protection Agency for evaluating laboratory and animal evidence of endocrine disruption. Expert panels used the Delphi method to make decisions on the strength of the data.
Expert panels achieved consensus at least for probable (>20%) EDC causation for IQ loss and associated intellectual disability, autism, attention-deficit hyperactivity disorder, childhood obesity, adult obesity, adult diabetes, cryptorchidism, male infertility, and mortality associated with reduced testosterone. Accounting for probability of causation and using the midpoint of each range for probability of causation, Monte Carlo simulations produced a median cost of €157 billion (or $209 billion, corresponding to 1.23% of EU gross domestic product) annually across 1000 simulations. Notably, using the lowest end of the probability range for each relationship in the Monte Carlo simulations produced a median range of €109 billion that differed modestly from base case probability inputs.
EDC exposures in the EU are likely to contribute substantially to disease and dysfunction across the life course with costs in the hundreds of billions of Euros per year. These estimates represent only those EDCs with the highest probability of causation; a broader analysis would have produced greater estimates of burden of disease and costs.
Sources and more information
- Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union, Endocrine Society, doi/pdf/10.1210/jc.2014-4324, March 05, 2015.
- Male Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union, Endocrine Society, doi/pdf/10.1210/jc.2014-4325, March 05, 2015.
- Obesity, Diabetes, and Associated Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union, Endocrine Society, doi/pdf/10.1210/jc.2014-4326, March 05, 2015.
- Neurobehavioral Deficits, Diseases and Associated Costs of Exposure to Endocrine Disrupting Chemicals in the European Union, Endocrine Society, doi/pdf/10.1210/jc.2014-4323, March 05, 2015.
- Chemical Exposure Linked to Billions in Health Care Costs, nationalgeographic, MARCH 5, 2015.