The in utero effects of diethylstilbestrol on the human male genital tract are reported in our followup study of male offspring of mothers treated with diethylstilbestrol. Anatomical and functional abnormalities were significantly greater in male patients exposed to diethylstilbestrol compared to male controls whose mothers were all participants in a prospective, randomized double-blind study on the effects of diethylstilbestrol on pregnancy at our hospital during the early 1950s. Epididymal cysts, hypotrophic testes and capsular induration of the testes were among the more common genital lesions found in more than 25 per cent of 159 male patients exposed to diethylstilbestrol compared to a 6.8 per cent incidence in 161 male controls. Spermatozoal analysis revealed severe pathological changes (Eliasson score more than 10) in 32 per cent of 31 patients exposed to diethylstilbestrol and 0 per cent of 20 male controls. Abnormal findings on physical examination combined with severe sperm abnormalities (Eliasson score more than 10) were found in 23 per cent of the male patients exposed to diethylstilbestrol versus none of the male controls. Cytologic examinations revealed no malignant cells from urine samples before and after prostatic massage or ejaculation, prostatic fluids and aspirates from epididymal cysts.
Sources: NCBI, J Urol. 1977 Apr;117(4):477-80., PMID: 850321, Pathological semen and anatomical abnormalities of the genital tract in human male subjects exposed to diethylstilbestrol in utero.
- Cancer Risk in Men exposed in Utero to DiEthylStilbestrol
- DES Exposure in Utero associated with Cryptorchidism, Testicular Hypoplasia, Semen Abnormalities
- Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
- Follow-up Study of Male and Female Offspring of DES-exposed Mothers
- Prenatal DiEthylStilbestrol Exposure in Males and Gender-related Disorders
- Reproductive Outcomes in Men with prenatal Exposure to DiEthylStilbestrol
- Effect of Estrogen/Androgen Perturbation on Penile Development in DiEthylStilbestrol-treated Mice
- Hypospadias in Sons of Women exposed to DiEthylStilbestrol in Utero
- Prevalence of HypoSpadias in GrandSons of Women exposed to DiEthylStilbestrol
- Structural and functional Abnormalities in the Sex Organs of Male Offspring of DES-treated Mothers
- Urogenital Abnormalities in Men exposed to DiEthylStilbestrol in Utero
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.
2 thoughts on “Pathological Semen and Anatomical Abnormalities of the Genital Tract in DES-Exposed Males”