Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived endocrine disruptor compounds Bisphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) at two different doses promoted epigenetic transgenerational inheritance of adult onset disease and associated DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to either the “plastics” or “lower dose plastics” mixture during embryonic days 8 to 14 of gonadal sex determination and the incidence of adult onset disease was evaluated in F1 and F3 generation rats. There were significant increases in the incidence of total disease/abnormalities in F1 and F3 generation male and female animals from plastics lineages. Pubertal abnormalities, testis disease, obesity, and ovarian disease (primary ovarian insufficiency and polycystic ovaries) were increased in the F3 generation animals. Kidney and prostate disease were only observed in the direct fetally exposed F1 generation plastic lineage animals. Analysis of the plastics lineage F3 generation sperm epigenome previously identified 197 differential DNA methylation regions (DMR) in gene promoters, termed epimutations. A number of these transgenerational DMR form a unique direct connection gene network and have previously been shown to correlate with the pathologies identified. Observations demonstrate that a mixture of plastic derived compounds, BPA and phthalates, can promote epigenetic transgenerational inheritance of adult onset disease. The sperm DMR provide potential epigenetic biomarkers for transgenerational disease and/or ancestral environmental exposures.
Maladies psychiques et troubles psychiatriques, l’autre scandale du DES
” Le Distilbène DES pourrait aussi être responsable de troubles psychiatriques. C’est, en tous cas, ce que soutient l’association Hhorages (Halte aux hormones artificielles pour les grossesses), rassemblant plus de mille familles dont les enfants sont victimes de dépressions sévères, d’anxiété, de troubles du comportement alimentaire, de schizophrénie, etc. …
… Le Distilbène appartient à la famille des perturbateurs endocriniens. Or, ces derniers sont capables de dérégler la machinerie qui régule les gènes à tous les niveaux, y compris celui du système nerveux central … ”
” My name is April Danann, and I am a DES Daughter. All the usual signs and symptoms including a bout with breast cancer in my early 30′s, multiple miscarriages and bicornate uterus. However, there is a rainbow in all of this – I have learned to take exquisite care of my body, brought it back to good health and have two healthy children (probably a miracle in itself!).
For many years I have refused to ‘take’ any form of drug (kind of gun-shy when it comes to meds, after all that is what caused these problems), choosing instead to treat myself and my family with natural methods, good diet, exercise, herbs and an inner belief in my body’s ability to heal itself.
My greatest achievement has been the free birth of my daughter a few years ago – it’s quite a story, but all down to DES and what we are now told about our bodies. If you would like to have a read about it, I posted the entire birth story on my blog (scroll down past the Food Revolution Article LOL). Perhaps, it will inspire others who are wanting children, trying to get their health back and not getting any answers.
Expenses for egg donors, or profit? Depends on whether you have ovaries
When The Human Fertilisation and Embryology Authority announced in 2011 that women who donate their eggs to infertile couples, will be rewarded an extra £500 in costs, Sara Stubblefield commented: ” I think this is reasonable. If you have ever been through this process as either a donor or someone going through IVF, you know that it isn’t as simple as going to the doctor on the right day and having them remove the egg with a little syringe. You have to take shots for days in your abdomen, go to the doctor 2-3 times a week for scans and ultrasounds and then have an outpatient procedure that requires anesthesia and a very scary needle. In addition, they give you enough hormones to mature about 20 eggs at once, instead of just one, so you’re exhausted, you’re emotional, your weight goes up and you just feel crappy all around. I think that 750 pounds is a more reasonable compensation amount, considering what you must endure to donate. ”
The new donating system in the UK is now the same as Spain but still a way off from the US, where donors receive up to £3,000 in costs.
What are your thoughts?
Cross-Disciplinary Team From Harvard and Dana-Farber Brings Novel Therapeutic Cancer Vaccine to Human Clinical Trials
A team from Harvard and Dana-Farber has launched a Phase I clinical trial of a therapeutic melanoma vaccine designed to reprogram a patient’s immune system to destroy tumors. The vaccine consists of a small disk-like, biodegradable sponge that’s infused with signaling molecules and components of the patient’s tumor.
The disk-shaped, biodegradable sponge contains growth factors and components of each patient’s tumors. Researchers at the Wyss Institute and clinicians at Dana-Farber Cancer Institute hope that when it’s implanted under the patient’s skin, it will spur the immune system to attack and destroy tumors.