Prenatal Diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
Read full study: Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study
NCBI, by Marie-Odile Soyer-Gobillard, 30 June 2011.
- L’Hypospadias chez les “petits-garçons DES” (3ème Génération) issus de “grands-mères Distilbène”, 2013
- Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study, NCBI, March 2002
- Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study, NCBI, August 2009